The Chamber rebutted Trump point-by-point, arguing that NAFTA has created 5 million jobs, that the United States is selling more to South Korea since signing a trade deal and that the Trans-Pacific Partnership would add $77 billion to the U.S. economy by 2025.
"Even under best case scenario, Trump's tariffs would strip us of at least 3.5 million jobs," the Chamber tweeted.
Jay Timmons, the president of the National Association of Manufacturers, also took aim at Trump in a series of critical tweets.
Directing his comments at Trump, he said that "you have it backward" and that "to win, WE need to write rules on trade -- not China."
He also tweeted: ".@realDonaldTrump should understand 40% of manufacturing jobs are related to exports. We need more exports-- not less."